Produce guitar recordings without guitaristic sounds and I don’t take the work seriously.  
No pick noise?  No idiosyncratic string bending or modern playing technique like tapping or harmonics on the track,  I don’t accept the track and hear it as inauthentic.  So? 

Eq for modern electric guitar is similar to capturing a female vocal.
Not only nuanced but
generous and kind to a fault eq is required. 
No rumble allowed.  Nothing below 60.  Leave the bottom for bass guitar please.  
The guts are in low mids.   
Intelligence and articulation is from mids and almost highs.  Highs are problematic because lead guitar has sheen.  A vital component of sheen are highs.  
At some point I will explain sheen as an extra cause.  But that is a discussion for later.  
I use little Fender amps with mods.  You don’t have one so get a preset on what is available as a start.  
Create some u shaped eq curves.  Cut at 200.  See if the guitar sits in the mix better.  Make additional decisions, cuts, based on how the guitar is sitting in the mix.  No adds. 
Go to a reference recording.  A performance of similar genre and instrumentation as your own recording.  
Does your eqd guitar stand up to the reference? 
Listen to the piece you are working on in your car and on an old stereo system.  Does it still sound good? 
Keep records of what your effective set up is, or you will be reinventing the wheel.  
Treat the lead voice as a female vocal.  Let her have her say on the track and make certain she is in the mix and not layered on top of it.  
Be easy to disparage whole genre of guitar music with the esthetics I have offered.  Not worth our time.  
If you are confused, listen to Steely Dan, The Royal Scam lp is a good place to start, and make your track sound as much as possible like that reference.  
Merry Christmas.  
Eq that mess!